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KMID : 0882420100790030321
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Korean Journal of Medicine
2010 Volume.79 No. 3 p.321 ~ p.326
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A case of adrenocortical adenoma with primary hyperaldosteronism and subclinical Cushing’s syndrome
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Hwang Byung-Hee
Yoo Ji-Yeon
Jung Jin-Hwan
Kim Sung-Rae
Yoo Soon-Jip
Kang Sung-ku
Le Seong-Su
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Abstract
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Cases of combined primary hyperaldosteronism and subclinical Cushing’s syndrome are extremely rare. We identified a left adrenocortical tumor in a 41-year-old woman by computed tomography (CT) during an evaluation for hypokalemia and hypertension. Hormonal assessment demonstrated normal aldosterone concentrations, low plasma renin activity, an increased aldosterone/renin ratio, and normal serum cortisol levels. Selective adrenal venous sampling for the determination of aldosterone concentrations showed an overfunctioning left adrenal gland. Dexamethasone (overnight 1mg, 2 mg, 8 mg) suppression tests showed insuppressible cortisol. We diagnosed the patient as having an aldosterone-producing adrenal adenoma associated with subclinical Cushing’s syndrome.
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KEYWORD
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Adrenocortical adenoma, Cushing’s syndrome, Hyperaldosteronism
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